Prerequisite concepts
Understanding both difference (how far apart two values are at one time) and change (how far apart the value of a single parameter is at two different times) is necessary for understanding derivatives.
The derivative is a ratio of small changes
One can view $\frac{df}{dx}$ as approximately given by a fraction where $df$ is a small change in $f$ and $dx$ is a small change in $x$.
Representations used
Technically, the derivative is a ratio of small changes in the limit that the change in the denominator goes to zero: $\frac{df}{dx}=\lim_{h \rightarrow 0} \frac{f(x+h)-f(x)}{h}$
In other words, $\frac{dy}{dx} = \frac{1}{\frac{dx}{dy}}$. Note that this concept is challenging to express in Newton's notation, but arises naturally if implicit differentiation is covered.
Taking derivatives of the same function with respect to different variables will produce different results. In physics, these different results might have different dimensions and thus the derivative can have wildly different physical interpretations based off of "'with respect to' what".
While it is relatively easy to imagine very, very small changes in physical values, there are often experimental limits on how small of a change can be measured. When designing and conducting experiments, there is a tension between these experimental limitations and normative representations of functions as smooth lines or
FIXME