Publications: {• Revs • PB-PD • PB-PhD } [2,989 total citations • H-index 25]

Research Papers {• 2020 • 2015 • 2010 • 2005 }
64. "Total Synthesis of Chalaniline A: An Aminofulvene Fused Chromone from Vorinostat-Treated Fungus Chalara sp. 6661," Prapapongpan, P.; Vanthiya, V.; Kwon, O.-S.; Zakharov, L. N.; Loesgen, S.; Blakemore,* P. R. J. Org. Chem. 2024, 89, 14601-14605. [LINK]
 
63. "Synthesis of [28-13C]-24-Methylenecholesterol Using 1-tert-Butyl-1H-tetrazol-5-yl [13C]-Methyl Sulfone to Methylenate an Isopropyl Ketone Intermediate," Quiroz, E. E.; Prapapongpan, P.; Resch, G.; Chakrabarti, P.; Sagili, R. R.; Blakemore,* P. R. ARKIVOC 2024, (2), 202312100. [LINK]
 
62. "Enantiocontrolled Connective Synthesis of Allenes by Carbenoid Eliminative Cross-Coupling between alpha-(Methylthio)vinylcuprate Species and alpha-(Carbamoyl-oxy)alkylboronates," Cao, Y.; Blakemore,* P. R. Synlett 2023, 34, 2200-2204. [LINK] 2 citations
 
61. "Synthesis of Thioalkynes by Desilylative Sonogashira Cross-Coupling of Aryl Iodides and 1-Methylthio-2-(trimethylsilyl)ethyne," Cao, Y.; Huang, Y.; Blakemore,* P. R. Eur. J. Org. Chem. 2022, e202200498. [LINK] 13 citations
 
60. "Stereospecific Synthesis of Conjugated Dienes by Carbenoid Eliminative Cross-Coupling Using Lithiated Allylic Carbamates," Tanpure, S. D.; Blakemore, P. R. * Eur. J. Org. Chem. 2021, 4932-4937. [LINK]
 

59.

 "Total Synthesis of Chalaniline B: An Antibiotic Aminoxanthone from Vorinostat-Treated Fungus Chalara sp. 6661," Khoshbakht, M.; Thanaussavadate, B.; Zhu, C.; Cao, Y.; Zakharov, L. N.; Loesgen, S.; Blakemore,* P. R. J. Org. Chem. 2021, 86, 7773-7780. [LINK] 3 citations
 

58.

"Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice," Paraiso, L. I.; Mattio, L. M.; Magaña, A. A.; Choi, J.; Plagmann, L. S.; Redick, M. A.; Miranda, C. L.; Maier,C. S.;  Dallavalle, S.; Kioussi, C.; Blakemore, P. R.; Stevens,* J. F. ACS Pharmacol. Transl. Sci. 2021, 4, 1782-1793. [LINK] 6 citations
 
57. "Synthesis of a P-Glycoprotein Inhibitor and Its High Energy (Z)-Isomer by Carbenoid Eliminative Cross-Coupling," Tanpure, S. D.; El-Mansy, M. F.; Blakemore,* P. R. Org. Lett. 2020, 22, 2999-3003. [LINK] 6 citations
 

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56. "Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism," Zhang, Y.; Bobe, G.; Revel, J. S.; Rodrigues, R. R.; Sharpton, T. J.; Fantacone, M. L.; Raslan, K.; Miranda, C. L.; Lowry, M. B.; Blakemore, P. R.; Morgun, A.; Shulzhenko, N.; Maier, C. S.; Stevens, J. F.; Gombart,* A. F. Mol. Nutr. Food Res. 2020, 64, 1900789. [LINK] 33 citations
   
55. "Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Inhibition of HIV-1 RNase H Activity by 7-Isopropyl-8-(naphth-1-yl)quinoline," Overacker, R. D.; Banerjee, S.; Neuhaus, G. F.; Milicevic Sephton, S.; Herrmann, A.; Strother, J. A.; Brack-Werner, R.; Blakemore, P. R.; Loesgen,* S. Bioorg. Med. Chem. 2019, 27, 3595-3604. [LINK] 23 citations
 

54. "Reductive Metabolism of Xanthohumol and 8-Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus," Paraiso, I. L.; Plagmann, L. S.; Yang, L.; Zielke, R.; Gombart, A. F.; Maier, C. S.; Sikora, A. E.; Blakemore, P. R.; Stevens,* J. F. Mol. Nutr. Food Res. 2019, 63, 1800923. [LINK] 41 citations
   
53. "Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet- induced Obese Mice," Miranda, C. L.; Johnson, L. A.; de Montgolfier, O.; Elias, V. D.; Ullrich, L. S.; Hay, J. J.; Paraiso, I. L.; Choi, J.; Reed, R. L.; Revel, J. S.; Kioussi, C.; Bobe, G.; Iwaniec, U. T.; Turner, R. T.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A.; Blakemore, P. R.; Gombart, A. F.; Maier, C. S.; Raber, J.; Stevens,* J. F. Sci. Reports 2018, 8:613. [LINK] 51 citations
   
52. "Total Synthesis of [13C]2-, [13C]3-, and [13C]5-Isotopomers of Xanthohumol, the Principal Prenylflavonoid From Hops," Ellinwood, D. C.; El-Mansy, M. F.; Plagmann, L. S.; Stevens, J. F.; Maier, C. S.; Gombart, A. F.; Blakemore,* P. R. J. Label. Compd. Radiopharm. 2017, 60, 639-648. [LINK] 7 citations
 

 
51.

"Stereospecific Synthesis of Alkenes by Eliminative Cross-Coupling of Enantioenriched sp3-Hybridized Carbenoids," Wu, Z.; Sun, X.; Potter, K.; Cao, Y.; Zakharov, L. N.; Blakemore,* P. R. Angew. Chem., Int. Ed. 2016, 55, 12285-12289. [LINK] 24 citations

 

  For an accompanying lay summary of this work, see: "Alkene Synthesis - Any Way You Want It," Blakemore,* P. R. Atlas of Science. [LINK]
50. "Trace Analysis of Surfactants in Corexit Oil Dispersant Formulations and Seawater," Place, B. J.; Perkins, M. J.; Sinclair, E.; Barsamian, A. L.; Blakemore, P. R.; Field,* J. A. Deep Sea Res. Part II 2016, 129, 273-281. [LINK] 36 citations
   
49. "Synthesis, Properties, and Enantiomerization Behavior of Axially Chiral Phenolic Derivatives of 8-(Naphth-1-yl)quinoline and Comparison to 7,7´-Dihydroxy-8,8´-biquinolyl and 1,1´-Bi-2-naphthol," Banerjee, S.; Riggs, B. E.; Zakharov, L. N.; Blakemore,* P. R. Synthesis 2015, 47, 4008-4016. [LINK] 11 citations
 

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48. "Enantioselective Synthesis of alpha-Phenyl- and alpha-(Dimethylphenylsilyl)- alkylboronic Esters by Ligand Mediated Stereoinductive Reagent-Controlled Homologation Using Configurationally Labile Carbenoids," Barsamian, A.L.; Wu, Z.; Blakemore,* P. R. Org. Biomol. Chem. 2015, 13, 3781-3786. [LINK] 22 citations
 

47. "On the Nature of the Chain-Extending Species in Organolithium Initiated Stereospecific Reagent-Controlled Homologation Reactions Using alpha-Chloroalkyl Aryl Sulfoxides," Hoyt, A. L.; Blakemore,* P. R. Tetrahedron Lett. 2015, 56, 2980-2982. [LINK] 9 citations
 

 
46. "Chain Extension of Boronic Esters with Lithiooxiranes Generated by Sulfoxide-Metal Exchange: Stereocontrolled Access to 2°/2°, 2°/3°, and 3°/3° Vicinal Diols and Related Compounds," Alwedi, E.; Zakharov, L. N.; Blakemore,* P. R. Eur. J. Org. Chem. 2014, 6643-6648. [LINK] 14 citations
 

 
45. "Enantioselective Synthesis of Biaryl Compounds via Suzuki–Miyaura Cross-Coupling Using a Palladium Complex of 7'-Butoxy-7-(diphenylphosphino)-8,8'-biquinolyl: Investigation of a New Chiral Ligand Architecture," Wu, Z.; Wang, C.; Zakharov, L. N.; Blakemore,* P. R. Synthesis 2014, 46, 678-685. [LINK] 12 citations
 

44. "Regioselective Syntheses of [13C]4-Labelled Sodium 1-Carboxy-2-(2-ethylhexyloxycarbonyl)ethanesulfonate and Sodium 2-Carboxy-1-(2-ethylhexyloxycarbonyl)-ethanesulfonate from [13C]4-Maleic Anhydride," Barsamian, A. L.; Perkins, M. J.; Field, J. A.; Blakemore,* P. R. J. Label. Compd. Radiopharm. 2014, 57, 397-401. [LINK] 2 citations
 

 
43. "Investigation of Functionalized alpha-Chloroalkyllithiums for a Stereospecific Reagent-Controlled Homologation Approach to the Analgesic Alkaloid (–)-Epibatidine," Emerson, C. R.; Zakharov, L. N.; Blakemore,* P. R. Chem. Eur. J. 2013, 19, 16342-16356. [LINK] 30 citations
 

 
42. "Programmed Synthesis of a Contiguous Stereotriad Motif by Triple Stereospecific Reagent-Controlled Homologation," Sun, X.; Blakemore,* P. R. Org. Lett. 2013, 15, 4500-4503. [LINK] 26 citations
 

 
41. "Silylcyanation of Aldehydes, Ketones, and Imines Catalyzed by a 6,6´-Bissulfonamide Derivative of 7,7´-Dihydroxy-8,8´-biquinolyl (azaBINOL)," Milicevic Sephton, S.; Wang, C.; Zakharov, L. N.; Blakemore,* P. R. Eur. J. Org. Chem. 2012, 3249-3260. [LINK] 4 citations
 

 
40. "Stereocontrolled Generation of alpha-Metalated S,O-Acetals by Sulfoxide-Ligand Exchange from Cyclic Dithioorthoformate Monooxides," Barsamian, A. L.; Blakemore,* P. R. Organometallics 2012, 31, 19-22. [LINK] 6 citations
 

 
39. "Synthesis of 7,7´-Dihydroxy-8,8´-biquinolyl (azaBINOL) via Pd-Catalyzed Directed Double C-H Functionalization of 8,8´-Biquinolyl: Emergence of an Atropos from a Tropos State," Wang, C.; Flanigan, D. M.; Zakharov, L. N.; Blakemore,* P. R. Org. Lett. 2011, 13, 4024-4027. [LINK] 19 citations
 

 
38. "Iterative Stereospecific Reagent-Controlled Homologation Using a Functionalized alpha-Chloroalkyllithium: Synthesis of Cyclic Targets Related to Epibatidine," Emerson, C. R.; Zakharov, L. N.; Blakemore,* P. R. Org. Lett. 2011, 13, 1318-1321. [LINK] 23 citations
 

 
37. "Spontaneous Symmetry Breaking During Interrupted Crystallization of an Axially Chiral Amino Acid Derivative," Sephton, M. A.; Emerson, C. R.; Zakharov, L. N.; Blakemore,* P. R. Chem. Commun. 2010, 46, 2094-2096. [LINK] 12 citations
 

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36. "Thieme Chemistry Journal Awardees - Where Are They Now? Stereoselective Synthesis of Z-Configured alpha,beta-Unsaturated Macrocyclic Lactones and Diolides by Intramolecular Julia-Kocienski Olefination," Giesbrecht, H. E.; Knight, B. J.; Tanguileg, N. R.; Emerson, C. R.; Blakemore,* P. R. Synlett 2010, 374-378. [LINK] 21 citations
 

 
35. "Total Synthesis of (±)-alpha-Isosparteine, (±)-beta-Isosparteine, and (±)-Sparteine From a Common Tetraoxobispidine Intermediate," Norcross, N. R.; Melbardis, J. P.; Ferris Solera, M.; Sephton, M. A.; Kilner, C.; Zakharov, L. N.; Astles, P. C.; Warriner, S. L.; Blakemore,* P. R. J. Org. Chem. 2008, 73, 7939-7951. [LINK] 37 citations
 

 
34. "Determination of pKa Values for Diether Derivatives of 7,7´-Dihydroxy-8,8´-biquinolyl: Dependence of Basicity on Interannular Dihedral Angle," Blakemore,* P. R.; Milicevic, S. D.; Perera, H.; Shvarev, A.; Zakharov, L. N. Synthesis 2008, 2271-2277. [LINK] 9 citations
 

 
33. "Enzymatic Resolution of 7,7´-Dihydroxy-8,8´-biquinolyl Dipentanoate and Its Conversion to 2,2´-Di-tert-butyl-7,7´-dihydroxy-8,8´-biquinolyl," Blakemore,* P. R.; Milicevic, S. D.; Zakharov, L. N. J. Org. Chem. 2007, 72, 9368-9371. [LINK] 18 citations
 

 
32. "Competing Reaction Pathways from alpha-Halo-alpha-protioalkyl Aryl Sulfoxides Initiated by Organometallic Reagents," Blakemore,* P. R.; Burge, M. S; Sephton, M. A. Tetrahedron Lett. 2007, 48, 3999-4002. [LINK] 15 citations
 

 
31. "Iterative Stereospecific Reagent-Controlled Homologation of Pinacol Boronates by Enantioenriched alpha-Chloroalkyllithium Reagents," Blakemore,* P. R.; Burge, M. S. J. Am. Chem. Soc. 2007, 129, 3068-3069. [LINK] 109 citations
 

 
30. "A Stereocontrolled Synthesis of beta-Isosparteine," Blakemore,* P. R.; Norcross, N. R.; Warriner, S. L.; Astles, P. C. Heterocycles 2006, 70, 609-617. 9 citations
 

 
29. "Resolution, Enantiomerization Kinetics, and Chiroptical Properties of 7,7´-Dihydroxy-8,8´-biquinolyl," Blakemore,* P. R.; Kilner, C.; Milicevic, S. D. J. Org. Chem. 2006, 71, 8212-8218. [LINK] 27 citations
 

 
28. "Reagent Controlled Asymmetric Homologation of Boronic Esters by Enantioenriched Main-Group Chiral Carbenoids," Blakemore,* P. R.; Marsden, S. P.; Vater, H. D. Org. Lett. 2006, 8, 773-776. [LINK] 83 citations
 

 
27. "A Practical Synthesis of (±)-alpha-Isosparteine from a Tetraoxobispidine Core," Blakemore,* P. R.; Kilner, C.; Norcross, N. R.; Astles, P. C. Org. Lett. 2005, 7, 4721-4724. [LINK] 26 citations
 

26. "Ethyl (Benzothiazol-2-ylsulfonyl)acetate: A New Reagent for the Stereoselective Synthesis of alpha,beta-Unsaturated Esters from Aldehydes," Blakemore,* P. R.; Ho, D. K. H.; Nap, W. M. Org. Biomol. Chem. 2005, 3, 1365-1368. [LINK] 62 citations
 

 
25. "Harnessing Anionic Rearrangments on the Benzenoid Ring of Quinoline for the Synthesis of 6,6´-Disubstituted 7,7´-Dihydroxy-8,8´-biquinolyls," Blakemore,* P. R.; Kilner, C.; Milicevic, S. D. J. Org. Chem. 2005, 70, 373-376. [LINK] 25 citations
 
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Patents
24.

"Xanthohumol Derivatives and Methods for Making and Using," Paraiso, I. L.; Stevens, J. F.; Blakemore, P. R.; Mattio, L. M. 2022/2023, WO2022173750, US20240051922, EP4291307.
Book Chapters and Review Articles
23. "Stereospecific Reagent-Controlled Homologation Using Carbenoids Generated by Sulfoxide-Metal Exchange," Blakemore, P. R. in Homologation Reactions: Reagents, Applications, and Mechanisms, 1st Edition; Pace, V. Ed.; Wiley - VCH: Berlin, 2023, Vol. 2, pp. 513-548.

 
22.

"The Catalytic Enantioselective Stetter Reaction," Flanigan, D. M.; Ozboya, K. E.; Tanpure, S. D.; Muñoz, A.; Blakemore, P. R.; Rovis, T. Org. React. 2021, 106, 1193-1332.
21. "Axially Chiral Phenolic Derivatives of 8,8'-Biquinolyl and 8-(Naphth-1-yl)quinoline as Platforms for Discovery: The Unfolding Story of the azaBINOLs," Blakemore, P. R. ARKIVOC 2020, part i, 61-95. [LINK] 1 citation
20.

"The Julia-Kocienski Olefination," Blakemore,* P. R.; Milicevic Sephton, S.; Ciganek, E. Org. React. 2018, 95, 1-422. [LINK][beta] 22 citations
19.

"Formation of Olefins by Eliminative Dimerization and Eliminative Cross-Coupling of Carbenoids: A Stereochemical Exercise," Blakemore,* P. R.; Hoffmann,* R. W. Angew. Chem., Int. Ed. 2018, 57, 390-407. [LINK] 15 citations
18. "Olefination of Carbonyl Compounds by Main-group Element Mediators," Blakemore, P. R. in Comprehensive Organic Synthesis, 2nd Edition; Knochel, P., Molander, G. A. Eds.; Elsevier: Oxford, 2014, Vol. 1, pp. 516-608. 23 citations
17. "7,7´-Dihydroxy-8,8´-biquinolyl," Blakemore,* P. R.; Milicevic, S. D. in Electronic Encyclopedia of Reagents for Organic Synthesis; Wiley: Chichester, 2008. 1 citation
16. "N-Heteroatom-Substituted Alkanamides," Blakemore, P. R. in Science of Synthesis; Thieme: Stuttgart, 2005, Vol. 21, pp. 833-906.
15. "The Synthesis of Polycavernoside A. An Example of a Conformationally Guided Macrolactonization," Blakemore, P. R.; White, J. D. in Strategies and Tactics of Organic Synthesis; Harmata, M. Ed.; Elsevier: New York, 2005, Vol. 6, pp. 173-210.
14. "The Modified Julia Olefination: Alkene Synthesis via the Condensation of Metallated Heteroarylalkylsulfones with Carbonyl Compounds," Blakemore, P. R. J. Chem. Soc., Perkin Trans. 1 2002, 2563-2585. [LINK] 620 citations
13. "Morphine, the Proteus of Organic Molecules," Blakemore, P. R.; White,* J. D. Chem. Commun. 2002, 1159-1168. [LINK] 105 citations
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Post-Doctoral Research Publications (with Prof. James D. White)
12.

"Total Synthesis of Polycavernoside A, A Lethal Toxin of the Red Alga Polycavernosa tsudai," Blakemore, P. R.; Browder, C. C.; Hong, J.; Lincoln, C. M.; Nagornyy, P. A.; Robarge, L. A.; Wardrop, D. J.; White,* J. D. J. Org. Chem. 2005, 70, 5449-5460. [LINK] 65 citations

11. "Total Synthesis of Rhizoxin D, a Potent Antimitotic Agent from the Fungus Rhizopus chinensis," White,* J. D.; Blakemore, P. R.; Green, N. J.; Hauser, E. B.; Holoboski, M. A.; Keown, L. E.; Nylund Kolz, C. S.; Phillips, B. W. J. Org. Chem. 2002, 67, 7750-7760. [LINK] 84 citations
10. "Conversion of Carbamates to Amidosulfones and Amides. Synthesis of the [14-C]-Labeled Antiobesity Agent Ro23-7637," White,* J. D.; Blakemore, P. R.; Milicevic, S.; Choudhry, S. C.; Cupano, J.; Serico, L. Org. Lett. 2002, 4, 1803-1806. [LINK] 18 citations
9. "Total Synthesis of the Marine Toxin Polycavernoside A via Selective Macrolactonization of a Trihydroxy Carboxylic Acid," White,* J. D.; Blakemore, P. R.; Browder, C. C.; Hong, J.; Lincoln,C. M.; Nagornyy, P. A.; Robarge, L. A.; Wardrop, D. J. J. Am. Chem. Soc. 2001, 123, 8593-8595. [LINK] 77 citations
8. "Transannular Nitrone Cycloaddition. A Stereocontrolled Entry to the Spirocyclic of Pinnaic Acid," White,* J. D.; Blakemore, P. R.; Korf, E. A.; Yokochi, A. F. T. Org. Lett. 2001, 3, 413-415. [LINK] 60 citations
7. "Asymmetric Synthesis of (+)-Loline, a Pyrrolizidine Alkaloid from Rye Grass and Tall Fescue," Blakemore, P. R.; Kim, S.-K.; Schulze, V. K.; White,* J. D.; Yokochi, A. F. T. J. Chem. Soc., Perkin Trans. 1 2001, 1831-1845. [LINK] 53 citations
6. "Asymmetric Synthesis of (+)-Loline," Blakemore, P. R.; Schulze, V. K.; White,* J. D. Chem. Commun. 2000, 1263-1264. [LINK] 32 citations
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Graduate Research Publications (with Prof. Philip J. Kocienski)
5. "1-tert-Butyl-1H-tetrazol-5-yl Sulfones in the Modified Julia Olefination," Kocienski,* P. J.; Bell, A.; Blakemore, P. R. Synlett 2000, 365-366. [LINK] 142 citations
4. "On the Julia Alkenylation Reaction in Vitamin D Synthesis. Isolation of Four Geometrical Isomers of Vitamin D4," Blakemore, P. R.; Grzywacz, P.; Kocienski,* P. J.; Marczak, S.; Wicha, J. Pol. J. Chem. 1999, 73, 1209-1217. 8 citations
3. "The Modified Julia Olefination in Vitamin D2 Synthesis," Blakemore, P. R.; Kocienski,* P. J.; Marzcak, S.; Wicha J. Synthesis 1999, 1209-1215. [LINK] 49 citations
2. "A Synthesis of Herboxidiene," Blakemore, P. R.; Kocienski,* P. J.; Morley, A.; Muir, K. J. Chem. Soc., Perkin Trans. 1 1999, 955-968. [LINK] 74 citations
1. "A Stereoselective Synthesis of trans-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1H-tetrazol-5-yl Sulfones," Blakemore, P. R.; Cole, W. J.; Kocienski,* P. J.; Morley, A. Synlett 1998, 26-28. [LINK] 673 citations

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Last modified: 11/06/2024 (PRB)