Selected Publications


Nyarko A, Song Y, Novacek J, Zidek L, Barbar, E. (2013) Multiple Recognition Motifs in Nucleoporin Nup159 Provide a Stable and Rigid Nup159:Dyn2 Assembly. J. Biol. Chem. 288, 2614-22.


Nyarko, A., Song, Y., & Barbar, E. (2012) Intrinsic disorder in dynein intermediate chain modulates its interaction with NudE and dynactin. J. Biol. Chem. 287, 24884-93.

Barbar E. (2012) Native disorder mediates binding of dynein to NudE and dynactin. Biochem Soc Trans. 40, 1009-13.

Powell JD, Barbar E, & Dreher TW*. (2011) Turnip yellow mosaic virus forms infectious particles without the native beta annulus structure and flexible coat protein N-terminus. Virology. 422(2):165-73. Epub 2011 Nov 10.


Nyarko, A. & Barbar, E.* (2011) Light chain dependent self-association of dynein intermediate chain. J. Biol. Chem. 286, 1556-66

Nyarko, A., Hall, J., Hall, A., Hare, M., Kremerskothen, J., & Barbar, E.* (2011) Conformational dynamics promote binding diversity of dynein light chain LC8. Biophysical Chemistry. 159, 41-7. Available online 6 May 2011.

Morgan, J.L., Song, Y., & Barbar, E.* (2011) Structural dynamics and multi-region interactions in dynein-dynactin recognition. J. Biol. Chem. 286, 39349-59

Barbar, E. & Nyarko A. (2011) Assembly and Regulation of Dynein Light Chains. Handbook of Dynein, CRC Press.


Hall, J., Song, Y., Karplus, P.A. & Barbar, E. (2010) The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J. Biol. Chem. 285, 22566-75.


Hall A, Parsonage D, Horita D, Karplus PA, Poole LB, & Barbar E. (2009) Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry 48, 5984-93.

Hall, J., Karplus, P.A. & Barbar, E. (2009) Multivalency in the assembly of intrinsically disordered dynein intermediate chain. J. Biol. Chem. 284, 33115-33121.

Benison, G., Chiodo, M.P., Karplus, P.A. & Barbar, E. (2009) Structural, thermodynamic, and kinetic effects of a phosphomimetic mutation in dynein light chain LC8. Biochemistry 48, 11381-11389.

Benison G, & Barbar E. (2009) NMR analysis of dynein light chain dimerization and interactions with diverse ligands. Methods Enzymol. 455, 237-58.


Benison G, Karplus PA, & Barbar E. (2008) The interplay of ligand binding and quaternary structure in the diverse interactions of dynein light chain LC8. J Mol Biol. 384, 954-66. Epub 2008 Oct 11.

Hall J, Hall A, Pursifull N, & Barbar E. (2008) Differences in dynamic structure of LC8 monomer, dimer, and dimer-peptide complexes. Biochemistry. 47, 11940-52. Epub 2008 Oct 23.

Barbar E. (2008) Dynein light chain LC8 is a dimerization hub essential in diverse protein networks. Biochemistry. 47, 503-8. Epub 2007 Dec 20.


Benison G, Berkholz DS, & Barbar E. (2007) Protein assignments without peak lists using higher-order spectra. J Magn Reson. 189, 173-81. Epub 2007 Sep 20.

Benison G, Karplus PA, & Barbar E. (2007) Structure and dynamics of LC8 complexes with KXTQT-motif peptides: swallow and dynein intermediate chain compete for a common site. J Mol Biol. 371, 457-68. Epub 2007 May 24.

Song Y, Benison G, Nyarko A, Hays TS, & Barbar E. (2007) Potential role for phosphorylation in differential regulation of the assembly of dynein light chains. J Biol Chem. 282, 17272-9. Epub 2007 Apr 11.


Benison G, Nyarko A, & Barbar E. (2006) Heteronuclear NMR identifies a nascent helix in intrinsically disordered dynein intermediate chain: implications for folding and dimerization. J Mol Biol. 362, 1082-93. Epub 2006 Aug 4.

Talbott M, Hare M, Nyarko A, Hays TS, & Barbar E. (2006) Folding is coupled to dimerization of Tctex-1 dynein light chain. Biochemistry. 45, 6793-800.

Deeb RS, Hao G, Gross SS, Laine M, Qiu JH, Resnick B, Barbar EJ, Hajjar DP, & Upmacis RK. (2006) Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite. J Lipid Res. 47, 898-911. Epub 2006 Feb 9.


Nyarko A, Cochrun L, Norwood S, Pursifull N, Voth A, & Barbar E. (2005) Ionization of His 55 at the dimer interface of dynein light-chain LC8 is coupled to dimer dissociation. Biochemistry. 44, 14248-55.


Nyarko A, Hare M, Hays TS, & Barbar E. (2004) The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8. Biochemistry. 43, 15595-603.

Wang, L., Hare, M., Hays, T. & Barbar, E. (2004) Dynein Light Chain LC8 Promotes the Assembly of the Coiled Coil Domain of Swallow Protein. Biochemistry 43, 4611-4620.

Barbar, E., & Hare, M. (2004) Characterization of the Cargo Attachment Complex of Dynein Using NMR and Mass Spectrometry. Methods in Enzymology - Energetics of Biological Macromolecules, Part D. 380, 219-241.

Makokha, M., Huang, Y. J., Montelione, G., Edison, A. S., & Barbar, E. (2004) The Solution Structure of the pH Induced Monomer of Dynein Light Chain from Drosophila. Protein Science 13, 727-734.


Nyarko, A., Hare M., Makokha, M & Barbar, E. (2003) Interactions of LC8 with N-terminal segments of the intermediate chain of cytoplasmic dynein. The Scientific World 3, 647-654.


Makokha, M., Hare, M., M. Li, Hays, T., & Barbar, E. (2002) Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74. Biochemistry 41, 4302-4311.


Barbar, E., Hare, M, Makokha, M., Barany, G., & Woodward, C. (2001) NMR-Detected order in core residues of denatured bovine pancreatic trypsin inhibitor. Biochemistry 40, 9734-9742.

Woodward, C., Barbar, E., Carulla, N., Battiste, J., & Barany, G. (2001) Experimental approaches to protein folding based on the concept of a slow hydrogen exchange core. Journal of Molecular Graphics and Modeling 19, 94-101.

Shpak, E., Barbar, E, Leykam, J., & Kieliszewski, M. (2001) Contiguous Hydroxyproline Residues Direct Hydroxyproline Arabinosylation in Nictiana Tabacum. J. Biol. Chem. 276, 11272-11278.

Barbar, E. Kleinman, B., Imhoff, D, M. Li,Hays, T., & Hare, M. (2001) Dimerization and Folding of LC8, A Highly Conserved Dynein Light Chain. Biochemistry 40, 1596-1605.


Barbar, E. (1999) NMR Characterization of Partially Folded and Unfolded Conformational Ensembles of Proteins. Peptide Science 51, 191-207.


Barbar, E., Hare, M., Daragan, V., Barany, G., & Woodward, C. (1998) Dynamics of an Ensemble of Partially Folded BPTI Conformations of Bovine Pancreatic Trypsin Inhibitor. Biochemistry 37, 7822-7833.


Barbar, E., Gross, C. M., Woodward, C., & Barany, G. (1997) Chemical Synthesis and Nuclear Magnetic Resonance Characterization of Partially Folded Proteins. Methods in Enzymology 289, 587-611.

Barbar, E., LiCata, V., Barany, G., & Woodward, C. (1997) Local Fluctuations and Global Unfolding of Partially Folded BPTI Detected by NMR. Biophysical Chemistry 64, 45-57.


Barany, G., Gross, C.M., Ferrer, M., Barbar, E., Pan, H., & Woodward, C. (1996) Optimized Methods for Chemical Synthesis of Bovine Pancreatic Trypsin Inhibitor Analogs, Techniques in Protein Chemistry VII (D. Marshak, ed.). Academic Press, San Diego, 503-514.

Barbar, E., Barany, G., & Woodward, C. (1996) Unfolded BPTI Variants with a Single Disulfide Bond Have Diminished Non-Native Structure Distant from the Crosslink.Folding & Design 1, 65-76.

Barbar, E., Martin, T.M., Brown, M. , Rittenberg, M.B., & Peyton, D.H. (1996) Binding of Phenylphosphocholine Carrier Conjugates to the Combining Site of Antibodies Maintains a Conformation of the Hapten, Biochemistry 35, 2958-2967.


Pan, H., Barbar, E., Barany G., & Woodward, C. (1995) Extensive Non-random Structure in Reduced and Unfolded Bovine Pancreatic Trypsin Inhibitor, Biochemistry 34, 13974-13981.

Barbar, E., Barany, G., & Woodward, C. (1995) Dynamic Structure of a Highly Ordered b-Sheet Molten Globule: Multiple Conformations with a Stable Core, Biochemistry 34, 11423-11434.

Wilson, N.A., Barbar, E., Fuchs, J., & Woodward, C. (1995) Aspartic Acid 26 in Reduced E. coli Thioredoxin has a pKa of 9, Biochemistry 34, 8931-8939.

Breslow, E., Sardana, V., Deeb, R., Barbar, E. and Peyton, D. H. (1995). The NMR Behavior of the Aromatic Protons of Bovine Neurophysin-I and its Peptide Complexes: Implications for Solution Structure and for Function, Biochemistry 34, 2137-2147.


Bruderer, U., Peyton, D.H., Barbar, E., Fellman, J.H., and Rittenberg, M.B. (1992). Hapten Conformation in the Combining Site of Antibodies that Bind Phenylphosphocholine, Biochemistry 31, 583-589.

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